The Wilms’ tumor suppressor WT1: Approaches to gene function
نویسندگان
چکیده
منابع مشابه
New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.
The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to the glomerular podocytes. Several human nephrotic diseases arise from mutations of the WT1 gene, including mutations that affect its zinc-fingers a...
متن کاملMultiple roles for the Wilms' tumor suppressor, WT1.
Wilms' tumor is a childhood kidney tumor that is a striking example of the way that cancer may arise through development gone awry. A proportion of these tumors develop as a result of the loss of function mutations in the Wilms' tumor suppressor gene, WT1. Inherited mutations in the WT1 gene can lead to childhood kidney cancer, severe gonadal dysplasia, and life-threatening hypertension. Knocko...
متن کاملWilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.
We analyzed Wilms' tumor suppressor 1 (WT1) expression and its regulation by promoter methylation in a panel of normal breast epithelial samples and primary carcinomas. Contrary to previous reports, WT1 protein was strongly expressed in primary carcinomas (27 of 31 tumors) but not in normal breast epithelium (1 of 20 samples). Additionally, the WT1 promoter was methylated in 6 of 19 (32%) prima...
متن کاملThe Wilms tumor suppressor gene wt1 is required for development of the spleen
The Wilms tumor suppressor gene WT1 (wt1 in mouse) is unique among tumor suppressors because, in addition to its involvement in cancer [1] [2] and various other diseases [3] [4] [5] [6], it has an essential role in the development of certain organs. This is revealed by the phenotype of mice with inactivated wt1 alleles [7]. These animals exhibit a complete failure of kidney and gonad developmen...
متن کاملThe Wilms’ Tumor Suppressor Wt1 Promotes Cell Adhesion Trhough Transcriptional Activation of the Α4integrin Gene
THE WILMS’ TUMOR SUPPRESSOR WT1 PROMOTES CELL ADHESION TRHOUGH TRANSCRIPTIONAL ACTIVATION OF THE α4INTEGRIN GENE Karin M. Kirschner, Nicole Wagner, Kay-Dietrich Wagner, Sven Wellmann, and Holger Scholz From the Institut für Vegetative Physiologie, Charité – Universitätsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany, INSERM U636, Centre de Biochimie, Faculté des Sciences, Parc Valrose...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.00935.x